(+)-YK-4-279

Product Name: (+)-YK-4-279
Synonyms: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-(3R)-2H-indol-2-oneMedchemexpress
Product Overview: A highly purified enantiomer of YK-4-279; properties have not been characterizedEwing’s sarcoma is characterized by the formation of an oncogenic fusion protein, EWS-FLI1, which binds to RNA helicase central to disease. YK-4-279 binds to EWS-FLI1 (K
Shipping: wet ice
CAS NO: 0 D8-MMAE
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C17H13Cl2NO4
SMILES: ClC1=CC=C(Cl)C(N2)=C1C(CC(C3=CC=C(OC)C=C3)=O)(O)C2=Oc-Kit inhibitors
Molecular Weight: 366.2
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/127/1/17

YK-4-279

Product Name: YK-4-279
Synonyms: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-oneWeb Site:Medchemexpress
Product Overview: blocks binding of RNA helicase A to ES-FLI1; induces apoptosis of Ewing’s sarcoma tumor cells (IC50 = 0.5-2 µM); reduces the growth of Ewing’s sarcoma orthotopic xenografts in miceES-FLI1 is an oncogenic fusion protein found in Ewing&rsq
Shipping: wet ice
CAS NO: 1454846-35-5 PF-06463922
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C17H13Cl2NO4
SMILES: ClC1=CC=C(Cl)C(N2)=C1C(O)(CC(C3=CC=C(OC)C=C3)=O)C2=ODeubiquitinase inhibitors
Molecular Weight: 366.2
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/54/8/3442.abstract