SCN1B Antibody

Background:
Voltage-gated sodium (Na+) channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. The complete coding region of Sodium channel,voltage-gated, beta 1(SCN1B) is found in approximately 9.0 kb of genomic DNA and consists of five exons (72 to 749 bp) and four introns (90 bp to 5.5 kb). It is mapped to 19q13.1 and can act as a candidate gene for hereditary disorders affecting membrane excitability.1 Sodium channel beta1 subunits play important roles in the regulation of sodium channel density and localization and are involved in axo-glial communication at nodes of Ranvier.2. PA000262-PA1244: SCN1B Polyclonal Antibody Rabbit Polyclonal Antibody. Specificity/Sensitivity: Human, rat, mouse. No cross reactivity with other proteins. Applications: WB 1 ug/ml. Reactivity: Human, Mouse, Rat. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human SCN1B, identical to the related rat and mouse sequence. Purification: Immunogen affinity purified. Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.