VCAM-1 Antibody

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|Introduction CD106(cluster of different 106) also known as vascular cell adhesion molecule 1(VCAM-1),is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in card allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arter expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. Cybulsky et al. (1991) mapped the VCAM1 gene to chromosome 1 by Southern analysis of somatic cell hybrids. Kumar et al. (1994) mapped the murine Vcam1 gene to chromosome 3 near Amy1.VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein med the adhesion of lymphocytes,monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothel cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated. | VCAM-1 Polyclonal Antibody Rabbit Polyclonal Antibody. Applications: WB: 0.1-0.5 ug/ml IHC-P: 0.5-1 ug/ml. Reactivity: Human, Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the C terminal of mouse CD106, different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.