SDHA Antibody

Background:
Complex II of the mitochondrial respiratory chain, also known as succinate dehydrogenase or succinate:ubiquinone oxidoreductase, consists of 4 nuclear-encoded polypeptides, these are the flavoprotein subunit (SDHA), the iron sulfur protein subunit (SDHB), and the integral membrane protein subunits SDHC and SDHD. SDHA is an acronym for succinate dehydrogenase complex subunit A. The succinate dehydrogenase (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The SDHA subunit is connected to the SDHB subunit on the hydrophilic, catalytic end of the complex, and weighs 72.7 kDA. Mutations in the SDHA subunit have a distinct pathology from mutations in the SDHB/SDHC/SDHD subunits; it is the only subunit to never have shown tumor suppressor behaviour. Heterozygous carriers of an SDHA mutation do not develop paragangliomas as has been seen for mutations in the other subunits. This appears to be due to the expression of two similar SDHA genes (Types I and II) in the paraganglia system.1. PA000270-PA1717: SDHA Polyclonal Antibody Rabbit Polyclonal Antibody. Applications: WB 0.1-0.5 ug/ml. Reactivity: Human, Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human SDHA, identical to the related rat and mouse sequences. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. Other SDHA Antibodies: SDHA Polyclonal Antibody SDHA Polyclonal Antibody