SHP-2 Antibody

Additional Information:
|Introduction PTPN11(Tyrosine-protein phosphatase non-receptor type 11), also known as protein-tyrosine phosphatase 1D (PTP-1D) , protein-tyrosine phosphatase 2C (PTP-2C) , TYROSINE PHOSPHATASE SHP2(SHP2), BPTP3, SH-PTP2, SHP-2, SH-PTP3, is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. The open reading frame consists of 1,779 nucleotides potent encoding a protein of 593 amino acids with a predicted molecular mass of 68 kD. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, different mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and med the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukem | SHP-2 PTPN11 Polyclonal Antibody Rabbit Polyclonal Antibody. Specificity/Sensitivity: Human, rat, mouse. No cross reactivity with other proteins. Applications: Western blot: At 1-2?g/ml with the appropr system to detect SHP-2 in cells and tissues. Immunohistochemistry(P): At 1-2?g/ml to detect SHP-2 in formalin fixed and |Human, Mouse, Rat. Immunogen: A synthetic peptide mapping at the C-terminal of human SHP-2, identical to the related rat sequence. Purification: Immunogen affinity purified. Form of Antibody: Each v contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.