Product Name :
Substance P peptide
Sequence Shortening :
RPKPQQFFGLM
Sequence :
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met
Length (aa) :
11
Peptide Purity (HPLC) :
96.4%
Molecular Formula :
C63H98N18O13S
Molecular Weight :
1347.6
Source :
Synthetic
Form :
Powder
Description :
It showed a good activity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity against S. mutans NCTC 10449 (MIC 171 ug/ml). NMR characterization in bicelles revealed a multiple turn structure or 3(10) helix (Gayen A et al 2011 Biochim Biophys Acta 1808:127-139). The bicelle-derived structure of substance P as a neurotransmitter was docked into the NK1R receptor. Updated 6/27/2011; 5/9/2014. Substance P has Antibacterial, Antifungal activity. Substance P was found in Homo sapiens.
Storage Guidelines :
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
References :
About TFA salt :
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process. TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product. TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations. In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
Related websites: https://www.medchemexpress.com/peptides/Peptide_Protein.html
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