Product Name :
Somatostatin-14 peptide
Sequence Shortening :
AGCKNFFWKTFTSC, disulfide bridge: 3-14
Sequence :
H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH
Length (aa) :
14
Peptide Purity (HPLC) :
97.3%
Molecular Formula :
C76H104N18O19S2
Molecular Weight :
1637.9
Source :
Synthetic
Form :
Powder
Description :
Somatostatin-14 (SRIF) was originally isolated from ovine hypothalamic extracts on the basis of its ability to inhibit the secretion of radioimmunoassayable growth hormone by primary cultures of enzymatically dispersed rat anterior pituitary cells. SRIF is a small cyclic neuropeptide hormone with broad inhibitory effects on endocrine secretions such as the production of GH, glucagon, and insulin.
Storage Guidelines :
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
References :
P.Brazeau et al., Science, 179, 77 (1973) A.Gomez-Pan and M.D.Rodriguez-Arnao, Clin. Endocrinol. Metab., 12, 469 (1983) G.Bissette and B.Myers, Life Sci., 51, 1389 (1992) G.Scalera, Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1399 (2003) W.van Grondelle et al., J. Struct. Biol., 160, 211 (2007) D.M.Petrovic-Dergovic et al., Neuropeptides, 41, 485 (2007) N.Nestorovic et al., Histochem. Cell Biol., 130, 699 (2008)
About TFA salt :
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process. TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product. TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations. In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
Related websites: https://www.medchemexpress.com/peptides/Peptide_Protein.html
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