HS014

Additional information:
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.{{Atropine sulfate} MedChemExpress|{Atropine sulfate} Neuronal Signaling|{Atropine sulfate} Biological Activity|{Atropine sulfate} In Vivo|{Atropine sulfate} supplier|{Atropine sulfate} Autophagy} 16, 108, 54.PMID:27102143 4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.|Product information|CAS Number: 207678-81-7|Molecular Weight: 1563.76|Formula: C71H94N20O17S2|Chemical Name: 3-[[2-[[1-[1-[25-acetamido-13-(3-carbamimidamidopropyl)-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(naphthalen-2-ylmethyl)-6, 9, 12, 15, 18, 21, 24-heptaoxo-1, 2-dithia-5, 8, 11, 14, 17, 20, 23-heptazacyclohexacosane-4-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-6-aminohexanoyl]amino]-4-amino-4-oxobutanoic acid|Smiles: CC(=O)NC1CSSCC(NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC2=CC3=CC=CC=C3C=C2)NC(=O)C(CC2=CNC=N2)NC(=O)C(CCC(O)=O)NC1=O)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(O)=O)C(N)=O|InChiKey: BRGDPINZISNYJL-UHFFFAOYSA-N|InChi: InChI=1S/C71H94N20O17S2/c1-38(92)81-53-35-109-110-36-54(69(107)91-26-10-18-56(91)70(108)90-25-9-17-55(90)68(106)85-46(15-6-7-23-72)62(100)86-49(60(73)98)31-59(96)97)82-57(93)34-79-61(99)51(29-42-32-78-45-14-5-4-13-44(42)45)88-63(101)47(16-8-24-77-71(74)75)83-65(103)50(28-39-19-20-40-11-2-3-12-41(40)27-39)87-66(104)52(30-43-33-76-37-80-43)89-64(102)48(84-67(53)105)21-22-58(94)95/h2-5,11-14,19-20,27,32-33,37,46-56,78H,6-10,15-18,21-26,28-31,34-36,72H2,1H3,(H2,73,98)(H,76,80)(H,79,99)(H,81,92)(H,82,93)(H,83,103)(H,84,105)(H,85,106)(H,86,100)(H,87,104)(H,88,101)(H,89,102)(H,94,95)(H,96,97)(H4,74,75,77)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively. Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate.|Products are for research use only. Not for human use.|