Product Name :
H-151
Description:
H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease.
CAS:
941987-60-6
Molecular Weight:
279.34
Formula:
C17H17N3O
Chemical Name:
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
Smiles :
CCC1C=CC(=CC=1)NC(=O)NC1=CNC2C=CC=CC=21
InChiKey:
UJZDIKVQFMCLBE-UHFFFAOYSA-N
InChi :
InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Streptomycin} MedChemExpress|{Streptomycin} Bacterial|{Streptomycin} Technical Information|{Streptomycin} In stock|{Streptomycin} manufacturer|{Streptomycin} Autophagy}
Additional information:
H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo.{{CNTF Protein, Mouse} MedChemExpress|{CNTF Protein, Mouse} Purity & Documentation|{CNTF Protein, Mouse} Purity|{CNTF Protein, Mouse} custom synthesis|{CNTF Protein, Mouse} Cancer} H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation.PMID:23865629 H-151 can be used for the research of autoinflammatory disease.|Product information|CAS Number: 941987-60-6|Molecular Weight: 279.34|Formula: C17H17N3O|Chemical Name: 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea|Smiles: CCC1C=CC(=CC=1)NC(=O)NC1=CNC2C=CC=CC=21|InChiKey: UJZDIKVQFMCLBE-UHFFFAOYSA-N|InChi: InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (447.48 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells. H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells. H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.|In Vivo:|H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice. H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter. H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.|Products are for research use only. Not for human use.|
