Product Name: VH298
Synonyms: (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamideMedchemexpress
Product Overview: A cell-permeant inhibitor of VHL (Kd = 90 nM by ITC); promotes the accumulation of HIF-α in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genesVH298 is a cell-permeant inhibitor of Von Hippel-Lindau disease
Shipping: dry ice
CAS NO: 7411-49-6 Product: DAB
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C27H33N5O4S
SMILES: O[[email protected]]1CN(C([[email protected]@H](NC(C2(C#N)CC2)=O)C(C)(C)C)=O)[[email protected]](C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)C1Apoptosis inhibitors
Molecular Weight: 523.7
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/48/8/2866.abstract