Product Name: Trametinib
Synonyms: N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-acetamide GWeb Site:Medchemexpress
Product Overview: A potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC50s = 0.7 and 0.9 nM, respectively); blocks dual phosphorylation of ERK1/2 and stops cell cycling in cancer cell lines, both in vitro and in multiple tumor models in mic
Shipping: wet ice
CAS NO: 1782235-14-6 Product: CHIR-99021 (trihydrochloride)
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C26H23FIN5O4
SMILES: CC(NC1=CC(N2C(C(C(N(C3CC3)C2=O)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C(C)C5=O)=CC=C1)=OAdenosine Deaminase inhibitors
Molecular Weight: 615.4
Formulation: A crystalline solid
Purity: ≥95%PubMed ID: