Thyroid Hormone Receptor Antagonist (1-850)

Product Name: Thyroid Hormone Receptor Antagonist (1-850)
Synonyms: 2-[1-(4-nitrophenyl)-4-piperidinylidene]-acetic acid-2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazideMedchemexpress
Product Overview: Selectively and competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 µM), demonstrating ~1000-fold lower affinity for TRα in intact cells compared with T3The activity of the thyroid hormones, L-thyroxine (T4; Item No. 14
Shipping: wet ice
CAS NO: 911417-87-3 SLx-2119
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C21H20F3N5O4
SMILES: O=C(NNC(/C=C1CCN(C2=CC=C([N+]([O-])=O)C=C2)CC/1)=O)NC3=CC(C(F)(F)F)=CC=C3PPAR inhibitors
Molecular Weight: 463.4
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/127/11/1426