SB-590885
SB-590885

SB-590885

Product Name: SB-590885
Synonyms: 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oximeMedchemexpress
Product Overview: A potent inhibitor of B-Raf (Kd = 0.3 nM) that less effectively inhibits c-Raf (Ki = 1.72 nM) and has little effect at 46 other kinases; blocks activation of ERK1/2 and anchorage-independent cell proliferation of melanoma cells with either wild type or V6
Shipping: wet ice
CAS NO: 1538604-68-0 BLU9931
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C27H27N5O2
SMILES: CN(C)CCOC1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(/C(CC5)=N/O)C5=C4)N2)C=C1Survivin inhibitors
Molecular Weight: 453.5
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/54/8/3489.abstract