Product Name: SB-525334
Synonyms: 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-quinoxaline TGF-β RI Kinase Inhibitor
Product Overview: A potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM); blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression; effective in vivo, preventing
Shipping: wet ice
CAS NO: 453562-69-1 Motesanib
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C21H21N5
SMILES: CC(C)(C)C(N1)=NC(C2=CC=CC(C)=N2)=C1C(C=C3)=CC4=C3N=CC=N4gamma)-secretase inhibitors
Molecular Weight: 343.4
Formulation: A crystalline solid
Purity: ≥98%PubMed ID: