Product Name: Ruxolitinib
Synonyms: βR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile INCB 018424Medchemexpress
Product Overview: A potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels o
Shipping: wet ice
CAS NO: 1628317-18-9 Product: MI-463
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C17H18N6
SMILES: N#CC[[email protected]](C1CCCC1)N(N=C2)C=C2C3=C4C(NC=C4)=NC=N3Hedgehog inhibitors
Molecular Weight: 306.4
Formulation: A crystalline solid
Purity: ≥98%PubMed ID: