PF-05274857 (hydrochloride)
PF-05274857 (hydrochloride)

PF-05274857 (hydrochloride)

Product Name: PF-05274857 (hydrochloride)
Synonyms: 1-[4-(5’-chloro-3,5-dimethyl[2,4’-bipyridin]-2’-yl)-1-piperazinyl]-3-(methylsulfonyl)-1-propanone, monohydrochlorideMedchemexpress
Product Overview: An antagonist which binds Smo (Ki = 4.6 nM), blocking Gli1 transcription in cells stimulated with Shh (IC50 = 2.7 nM); orally available, metabolically stable, and able to penetrate the blood-brain barrierSonic hedgehog (Shh) signaling is initiated by bind
Shipping: wet ice
CAS NO: 204697-65-4 Olcegepant
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C20H25ClN4O3S • HCl
SMILES: ClC1=C(C2=NC=C(C)C=C2C)C=C(N3CCN(C(CCS(C)(=O)=O)=O)CC3)N=C1.ClProtease_Inhibitor_Cocktail inhibitors
Molecular Weight: 473.4
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/129/7/883