MK-4827 (tosylate)
MK-4827 (tosylate)

MK-4827 (tosylate)

Product Name: MK-4827 (tosylate)
Synonyms: 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide, 4-methylbenzenesulfonate Niraparib
Product Overview: An orally bioavailable inhibitor of PARP1 and PARP2 (IC50s = 3.8 and 2.1 nM, respectively); inhibits the proliferation of BRCA1 and BRCA2 mutant cancer cells in vitro (IC50s = 10-100 nM) and has efficacy alone against a xenograft of BRCA1-deficient cancer
Shipping: dry ice
CAS NO: 900814-48-4 Product: AVX 13616
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C19H20N4O • C7H8O3S
SMILES: NC(C1=CC=CC2=CN(C3=CC=C([[email protected]]4CNCCC4)C=C3)N=C21)=O.CC5=CC=C(S(O)(=O)=O)C=C5PPAR inhibitors
Molecular Weight: 492.6
Formulation: A crystalline solid
Purity: ≥98%PubMed ID: