Product Name: GSK126
Synonyms: N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamideMedchemexpress
Product Overview: A selective, SAM-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM); inhibits global H3K27me3 levels, inhibiting the proliferation of EZH2 mutant DLBCL cell
Shipping: wet ice
CAS NO: 1384426-12-3 NT157
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C31H38N6O2
SMILES: CC1=CN([C@@H](C)CC)C2=CC(C(C=C3)=CN=C3N4CCNCC4)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C21GPR139 inhibitors
Molecular Weight: 526.7
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/129/1/22
