FK-506
FK-506

FK-506

Product Name: FK-506
Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-eMedchemexpress
Product Overview: A potent, clinically-useful immunosuppressant; binds to FK-506 binding protein 12 (Ki = 0.2 nM) to inhibit calcineurin; regulates NO neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and IP3 receptorsFK-506 is a pot
Shipping: wet ice
CAS NO: 1374639-75-4 LEE011 (succinate)
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C44H69NO12
SMILES: O=C([[email protected]@](CCCC1)([H])N1C(C([[email protected]@]2(O)[[email protected]](C)C[[email protected]](OC)[[email protected]@](O2)([H])[[email protected]@H](OC)C[[email protected]@H](C)C/C(C)=C/[[email protected]]3CC=C)=O)=O)O[[email protected]](/C(C)=C/[[email protected]]4C[[email protected]@H](OC)[[email protected]](O)CC4)[[email protected]](C)[[email protected]@H](O)CC3=OBacterial inhibitors
Molecular Weight: 804
Formulation: A crystalline solid
Purity: ≥99%PubMed ID:http://aac.asm.org/content/54/7/3015.abstract