Product Name: Defactinib
Synonyms: N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-benzamide PMedchemexpress.com
Product Overview: A dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 µM; restores the chemosensitivity of taxane-resistant cells to paclitaxel; orally bioavailable, inhibiting FAK and augmenting paclitaxel ac
Shipping: wet ice
CAS NO: 123464-89-1 Product: PNU-282987
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C20H21F3N8O3S
SMILES: O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(C)(=O)=O)=N2)C=C1VEGFR inhibitors
Molecular Weight: 510.5
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/57/9/4595.abstract
