Product Name: WZ4002
Synonyms: N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamideWeb Site click
Product Overview: An irreversible EGFR tyrosine kinase inhibitor that blocks ATP-dependent autophosphorylation of EGFR carrying the T790M mutation as well as an L858R mutation (IC50 = 8 nM); effective in mouse models of lung cancer driven by EGFRT790MThe recurrent missense
Shipping: wet ice
CAS NO: 473727-83-2 SCH 527123
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C25H27ClN6O3
SMILES: CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(OC4=CC=CC(NC(C=C)=O)=C4)=N3)C(OC)=C2)CC1Cathepsin inhibitors
Molecular Weight: 495
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/54/5/2112.abstract
