Product Name: SGC0946
Synonyms: 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineMedchemexpress
Product Overview: A potent inhibitor of DOT1L (IC50 = 0.3 nM); over 100-fold selective over other PMTs; active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively)Dot1L is a protein methyltransferase (PMT). It is the only e
Shipping: wet ice
CAS NO: 685898-44-6 PX-478
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C28H40BrN7O4
SMILES: CC(C)(C)C1=CC=C(NC(NCCCN(C(C)C)C[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C(Br)=C3)O2)=O)C=C1HIF_HIF Prolyl-Hydroxylase inhibitors
Molecular Weight: 618.6
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/118/21/3689
