Product Name: Refametinib
Synonyms: N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]-cyclopropanesulfonamide RDEA119 Web Site click
Product Overview: An allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively); blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM); orally available a
Shipping: wet ice
CAS NO: 1628428-01-2 Product: PKR-IN-2
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C19H20F3IN2O5S
SMILES: FC1=CC(OC)=C(NS(C2(CC2)C[C@H](O)CO)(=O)=O)C(NC3=CC=C(I)C=C3F)=C1FThymidylate Synthase inhibitors
Molecular Weight: 572.3
Formulation: A crystalline solid
Purity: ≥95%PubMed ID:http://aac.asm.org/content/55/12/5624.abstract
