Product Name: RKI-1447
Synonyms: N-[(3-hydroxyphenyl)methyl]-N-[4-(4-pyridinyl)-2-thiazolyl]-ureaMedchemexpress.com
Product Overview: A ROCK-I and II inhibitor (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase; suppresses the activation of ROCK substrates MLC-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 at 100 nM in cancer
Shipping: wet ice
CAS NO: 59803-98-4 Product: UK 14,304
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C16H14N4O2S
SMILES: OC1=CC(CNC(NC2=NC(C3=CC=NC=C3)=CS2)=O)=CC=C1ROS inhibitors
Molecular Weight: 326.4
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/58/6/3177.abstract
