Product Name: PF-8380
Synonyms: 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acidMedchemexpress
Product Overview: A potent inhibitor of autotaxin (IC50 = 2.8 nM in an in vitro enzyme assay); at 30 mg/kg, reduces LPA production by >95% following carrageenan-induced inflammation in rats and inhibits autotaxin activity in human whole blood (IC50 = 101 nM)Autotaxin co
Shipping: wet ice
CAS NO: 747412-49-3 NVP-AUY922
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C22H21Cl2N3O5
SMILES: O=C(C1=CC(OC(N2)=O)=C2C=C1)CCN3CCN(C(OCC4=CC(Cl)=CC(Cl)=C4)=O)CC3Telomerase inhibitors
Molecular Weight: 478.3
Formulation: A crystalline solid
Purity: ≥95%PubMed ID:http://www.bloodjournal.org/content/129/3/358
