Product Name: NVP-BSK805 (hydrochloride)
Synonyms: 4-(2,6-difluoro-4-(3-(1-(pip4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine, dihydrochlorideMedchemexpress
Product Overview: A potent inhibitor of JAK2 that also inhibits the JAK2V617F mutant enzyme (IC50s for both enzymes ~ 0.5 nM); orally bioavailable with a long half-life in vivo, suppressing leukemic cell spreading and splenomegaly in JAK2V617F cell-driven disease in miceJa
Shipping: wet ice
CAS NO: 343787-29-1 CP-673451
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C27H28F2N6O • 2HCl
SMILES: FC1=C(CN2CCOCC2)C(F)=CC(C3=CC=CC4=C3N=C(C5=CN(C6CCNCC6)N=C5)C=N4)=C1.Cl.ClDNA Stain inhibitors
Molecular Weight: 563.5
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/129/21/2873
