Product Name: LDN-193189 (hydrochloride)
Synonyms: 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, monohydrochloride DM-3189Medchemexpress.com
Product Overview: Inhibits BMP type I receptor-induced phosphorylation of SMAD1/5/8 (IC50 = 4.9 nM); shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively)LDN-193189 inhibits SMAD1/5
Shipping: wet ice
CAS NO: 415713-60-9 Product: RI-1
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C25H22N6 • HCl
SMILES: N1(C2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC6=C5C=CC=C6)C=N4)C=C2)CCNCC1.ClFDA-approved_Drug_Library inhibitors
Molecular Weight: 443
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/60/6/3759.abstract
