Product Name: GZD-824
Synonyms: 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-benzamideWeb Site click
Product Overview: Inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively); suppresses proliferation of Bcr/Abl-positive K562 and Ku812 CML cells (IC50s = 0.2 and 0.13 nM, respectively)
Shipping: dry ice
CAS NO: 91809-66-4 Product: 5-TAMRA
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C29H27F3N6O
SMILES: CN1CCN(CC2=CC=C(NC(C3=CC(C#CC4=CN=C(NN=C5)C5=C4)=C(C)C=C3)=O)C=C2C(F)(F)F)CC1NF-κB inhibitors
Molecular Weight: 532.6
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/48/7/2437.abstract