Product Name: GDC-0449
Synonyms: 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide VismodegibMedchemexpress
Product Overview: A potent antagonist of SMO that acts in a biphasic manner, with apparent high affinity (Ki = 1.3 nM) and low affinity (Ki = 2.3 µM) binding; suppresses Gli-mediated transcription in CALU-6 tumors with an IC50 of 13 nM and prevents hedgehog-dependent
Shipping: wet ice
CAS NO: 1260907-17-2 GSK 525762A
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C19H14Cl2N2O3S
SMILES: ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3G-quadruplex inhibitors
Molecular Weight: 421.3
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/54/2/804.abstract
