Product Name: Entrectinib
Synonyms: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-benzamide NMS-E628 Web Site click
Product Overview: An inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as ROS1 (IC50 = 0.2 nM) and ALK (IC50 = 1.6 nM); blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations; in
Shipping: wet ice
CAS NO: 758683-21-5 Product: Bay 65-1942 (R form)
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C31H34F2N6O2
SMILES: O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=CC=C(N5CCN(C)CC5)C=C4NC6CCOCC6FXR inhibitors
Molecular Weight: 560.6
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/60/5/2881.abstract
