Product Name: CEP-32496
Synonyms: N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-ureaMedchemexpress
Product Overview: A potent inhibitor of B-RafV600E (Kd = 14 nM in an in vitro binding assay); blocks B-RafV600E–dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s = 78 and 60 nM, respectively); displays good oral bioav
Shipping: wet ice
CAS NO: 221244-14-0 Product: 1-NM-PP1
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C24H22F3N5O5
SMILES: COC1=C(OC)C=C(C(OC2=CC=CC(NC(NC3=NOC(C(C)(C)C(F)(F)F)=C3)=O)=C2)=NC=N4)C4=C1GPR55 inhibitors
Molecular Weight: 517.5
Formulation: A crystalline solid
Purity: ≥95%PubMed ID:http://aac.asm.org/content/59/7/3935.abstract
