Product Name: BGJ398
Synonyms: N-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-urea NVP-BGJ398 Web Site click
Product Overview: A pan FGFR inhibitor (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively); suppresses proliferation of cancer cells with wild-type FGFR3 overexpression and in an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3B
Shipping: wet ice
CAS NO: 1260907-17-2 Product: GSK 525762A
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C26H31Cl2N7O3
SMILES: COC1=C(Cl)C(NC(N(C)C2=CC(NC3=CC=C(N4CCN(CC)CC4)C=C3)=NC=N2)=O)=C(Cl)C(OC)=C1Metabolism/Protease_Compound_Library inhibitors
Molecular Weight: 560.5
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/60/7/4055.abstract
