Product Name: Avitinib
Synonyms: N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide AC0010Web Site click
Product Overview: A selective inhibitor of mutant EGFR that exhibits a 298-fold increase in potency compared with wild-type EGFR; oral administration at 500 mg/kg regresses tumors with EGFR-active and T790M mutations in a xenograft modelAvitinib is a pyrrolopyrimidine-base
Shipping: dry ice
CAS NO: 1394076-92-6 Product: GNE-317
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C26H26FN7O2
SMILES: CN1CCN(C2=C(F)C=C(NC3=NC(OC4=CC(NC(C=C)=O)=CC=C4)=C(C=CN5)C5=N3)C=C2)CC1Cytochrome P450 inhibitors
Molecular Weight: 487.5
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/47/7/2310.abstract
