Product Name :
XL-784 free base
Description:
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively.
CAS:
1356992-21-6
Molecular Weight:
549.93
Formula:
C21H22ClF2N3O8S
Chemical Name:
2-methoxyethyl 4-[4-(4-chlorophenoxy)-3,5-difluorobenzenesulfonyl]-3-(hydroxycarbamoyl)piperazine-1-carboxylate
Smiles :
COCCOC(=O)N1CC(C(=O)NO)N(CC1)S(=O)(=O)C1=CC(F)=C(OC2C=CC(Cl)=CC=2)C(F)=C1
InChiKey:
PRIJGYZAOBNIPH-UHFFFAOYSA-N
InChi :
InChI=1S/C21H22ClF2N3O8S/c1-33-8-9-34-21(29)26-6-7-27(18(12-26)20(28)25-30)36(31,32)15-10-16(23)19(17(24)11-15)35-14-4-2-13(22)3-5-14/h2-5,10-11,18,30H,6-9,12H2,1H3,(H,25,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively.|Product information|CAS Number: 1356992-21-6|Molecular Weight: 549.93|Formula: C21H22ClF2N3O8S|Chemical Name: 2-methoxyethyl 4-[4-(4-chlorophenoxy)-3,5-difluorobenzenesulfonyl]-3-(hydroxycarbamoyl)piperazine-1-carboxylate|Smiles: COCCOC(=O)N1CC(C(=O)NO)N(CC1)S(=O)(=O)C1=CC(F)=C(OC2C=CC(Cl)=CC=2)C(F)=C1|InChiKey: PRIJGYZAOBNIPH-UHFFFAOYSA-N|InChi: InChI=1S/C21H22ClF2N3O8S/c1-33-8-9-34-21(29)26-6-7-27(18(12-26)20(28)25-30)36(31,32)15-10-16(23)19(17(24)11-15)35-14-4-2-13(22)3-5-14/h2-5,10-11,18,30H,6-9,12H2,1H3,(H,25,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (454.60 mM; Need ultrasonic).Tideglusib Stem Cell/Wnt |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Capmatinib Protocol |Shelf Life: ≥12 months if stored properly.PMID:35134202 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|XL-784 is a highly potent, low-molecular-weight (1,122 g/mol) inhibitor of MMPs that has very limited aqueous solubility (20 μg/mL). XL-784 potently inhibits MMP-2, MMP-13, andADAM10 [TNF-α-converting enzyme (TACE)] activity in vitro, with IC50 values in the range of 1-2 nM. XL-784 also inhibits MMP-9 (IC50 ~20 nM) activity and ADAM17 (IC50 ~70 nM) also known as TACE. However, it exhibits low potency for inhibition of MMP-1 (IC50 ~2,000 nM).|In Vivo:|All mice tolerate the treatments similarly. Control mice all developed aneurysms with a mean %△AD of 158.5%±4.3%. Treatment with all doses of XL-784 and doxycycline are effective in inhibiting aortic dilatation. There is a clear dose-response relationship between XL-784 and reductions in aortic dilatation at harvest (50 mg/kg 140.4% ±3.2%; 125 mg/kg 129.3% ±5.1%; 250 mg/kg 119.2%±3.5%; all PsProducts are for research use only. Not for human use.|
