Product Name :
Rabbit anti-Ubiquitin Recombinant Monoclonal Antibody(R095)
Synonym :
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
Predicted Reactivity:
Applications :
WB: 1:1000, IHC-P: 1:2000
Immunogen:
Concentration :
0.5 mg/mL
Purification :
Protein A affinity column
Clonality:
Monoclonal Antibody
Storage Temp.:
Store at -20 ℃ for one year
Research areas :
Background :
Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the ‘ubiquitin code’. Ubiquitin can be ubiquitinated on seven lysine (Lys) residues or on the N-terminus, leading to polyubiquitin chains that can encompass complex topologies. Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8). Finally, ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and each modification has the potential to dramatically alter the signaling outcome [PMID: 27012465].
UniProt :
P62987, P0CG48, P0CG47, P62979
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB: 1:1000, IHC-P: 1:2000 |Properties |Form liquid |Concentration 0.5 mg/mL |Purification Protein A affinity column |Clonality Monoclonal Antibody |Clone R095 |Storage Temp. Store at -20 ℃ for one year |Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |Target |Background Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the ‘ubiquitin code’. Ubiquitin can be ubiquitinated on seven lysine (Lys) residues or on the N-terminus, leading to polyubiquitin chains that can encompass complex topologies. Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8). Finally, ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and each modification has the potential to dramatically alter the signaling outcome [PMID: 27012465]. |Cellular localization Cytoplasm, Nucleus |UniProt P62987, P0CG48, P0CG47, P62979 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-Ubiquitin Recombinant Monoclonal Antibody(R095)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
1799633-27-4 medchemexpress 2805997-46-8 Biological Activity PMID:29083794 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
