(+)-JQ1

Product Name: (+)-JQ1
Synonyms: (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 1,1-dimethylethyl esterMedchemexpress
Product Overview: Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains; binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectivelyThe bromodomain and extra terminal domain (BET) family
Shipping: wet ice
CAS NO: 1415716-58-3 TG6-10-1
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C23H25ClN4O2S
SMILES: ClC1=CC=C(C=C1)C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4TRP Channel inhibitors
Molecular Weight: 457
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://www.bloodjournal.org/content/127/6/787