AMG 337
AMG 337

AMG 337

Product Name: AMG 337
Synonyms: 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-oneMedchemexpress
Product Overview: A selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, which subsequently blocks downstream PI3K and MAPK pathways; inhibits cell proliferation in various c-Met-dependent tumor modelsAMG 337 is an orally ac
Shipping: dry ice
CAS NO: 3326-31-6 Product: 6-FITC
Stability: Store at -20 degrees; shelf life 730 days maximum after production
Molecular Formula: C23H22FN7O3
SMILES: COCCOC1=CN=C(C=CN([[email protected]](C)C2=NN=C3N2C=C(C4=CN(C)N=C4)C=C3F)C5=O)C5=C1Keap1-Nrf2 inhibitors
Molecular Weight: 463.5
Formulation: A crystalline solid
Purity: ≥98%PubMed ID:http://aac.asm.org/content/48/7/2448.abstract